Site-specific phosphorylation of Fbxw7 by Cdk5/p25 and its resulting decreased stability are linked to glutamate-induced excitotoxicity

Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine protein kinase that regulates brain development and neurodegeneration. Cdk5 is activated by p25 that is generated from calpain-dependent cleavage of p35. The generation of p25 is responsible for the aberrant hyper-activation of Cdk5, which cause...

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Detalles Bibliográficos
Autores principales: Ko, Yeon Uk, Kim, Chiho, Lee, Juhyung, Kim, Dana, Kim, Yoonkyung, Yun, Nuri, Oh, Young J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675790/
https://www.ncbi.nlm.nih.gov/pubmed/31371703
http://dx.doi.org/10.1038/s41419-019-1818-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675790/
https://www.ncbi.nlm.nih.gov/pubmed/31371703
http://dx.doi.org/10.1038/s41419-019-1818-4

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