Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress

Familial early-onset forms of Alzheimer's disease (AD) are linked to overproduction of amyloid beta (Aβ) peptides, while decreased clearance of Aβ is the driving force leading to its toxic accumulation in late-onset (sporadic) AD. Oxidative modifications and defective function have been reporte...

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Detalles Bibliográficos
Autores principales: de Dios, Cristina, Bartolessis, Isabel, Roca-Agujetas, Vicente, Barbero-Camps, Elisabet, Mari, Montserrat, Morales, Albert, Colell, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675974/
https://www.ncbi.nlm.nih.gov/pubmed/31376793
http://dx.doi.org/10.1016/j.redox.2019.101283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675974/
https://www.ncbi.nlm.nih.gov/pubmed/31376793
http://dx.doi.org/10.1016/j.redox.2019.101283

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