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Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress
Familial early-onset forms of Alzheimer's disease (AD) are linked to overproduction of amyloid beta (Aβ) peptides, while decreased clearance of Aβ is the driving force leading to its toxic accumulation in late-onset (sporadic) AD. Oxidative modifications and defective function have been reporte...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675974/ https://www.ncbi.nlm.nih.gov/pubmed/31376793 http://dx.doi.org/10.1016/j.redox.2019.101283 |