Structure of formylglycine-generating enzyme in complex with copper and a substrate reveals an acidic pocket for binding and activation of molecular oxygen

The formylglycine generating enzyme (FGE) catalyzes oxidative conversion of specific peptidyl-cysteine residues to formylglycine. FGE mediates O(2)-activation and hydrogen-atom abstraction in an active site that contains Cu(i) coordinated to two cysteine residues. Similar coordination geometries are...

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Detalles Bibliográficos
Autores principales: Miarzlou, Dzmitry A., Leisinger, Florian, Joss, Daniel, Häussinger, Daniel, Seebeck, Florian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676471/
https://www.ncbi.nlm.nih.gov/pubmed/31588272
http://dx.doi.org/10.1039/c9sc01723b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676471/
https://www.ncbi.nlm.nih.gov/pubmed/31588272
http://dx.doi.org/10.1039/c9sc01723b

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