Cargando…
Interactions between a subset of substrate side chains and AAA+ motor pore loops determine grip during protein unfolding
Most AAA+ remodeling motors denature proteins by pulling on the peptide termini of folded substrates, but it is not well-understood how motors produce grip when resisting a folded domain. Here, at single amino-acid resolution, we identify the determinants of grip by measuring how substrate tail sequ...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677533/ https://www.ncbi.nlm.nih.gov/pubmed/31251172 http://dx.doi.org/10.7554/eLife.46808 |