PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

NORAD is a conserved long noncoding RNA (lncRNA) that is required for genome stability in mammals. NORAD acts as a negative regulator of PUMILIO (PUM) proteins in the cytoplasm, and we previously showed that loss of NORAD or PUM hyperactivity results in genome instability and premature aging in mice...

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Detalles Bibliográficos
Autores principales: Elguindy, Mahmoud M, Kopp, Florian, Goodarzi, Mohammad, Rehfeld, Frederick, Thomas, Anu, Chang, Tsung-Cheng, Mendell, Joshua T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677556/
https://www.ncbi.nlm.nih.gov/pubmed/31343408
http://dx.doi.org/10.7554/eLife.48625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677556/
https://www.ncbi.nlm.nih.gov/pubmed/31343408
http://dx.doi.org/10.7554/eLife.48625

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