Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1

Tropomyosins (Tpm) determine the functional capacity of actin filaments in an isoform-specific manner. The primary isoform in cancer cells is Tpm3.1 and compounds that target Tpm3.1 show promising results as anti-cancer agents both in vivo and in vitro. We have determined the molecular mechanism of...

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Detalles Bibliográficos
Autores principales: Janco, Miro, Rynkiewicz, Michael J., Li, Liang, Hook, Jeff, Eiffe, Eleanor, Ghosh, Anita, Böcking, Till, Lehman, William J., Hardeman, Edna C., Gunning, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677793/
https://www.ncbi.nlm.nih.gov/pubmed/31375704
http://dx.doi.org/10.1038/s41598-019-47592-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677793/
https://www.ncbi.nlm.nih.gov/pubmed/31375704
http://dx.doi.org/10.1038/s41598-019-47592-9

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