Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding

Functional variants in the genome are usually identified by their association with local gene expression, DNA methylation or chromatin states. DNA sequence motif analysis and chromatin immunoprecipitation studies have provided indirect support for the hypothesis that functional variants alter transc...

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Detalles Bibliográficos
Autores principales: Johnston, Andrew D., Simões-Pires, Claudia A., Thompson, Taylor V., Suzuki, Masako, Greally, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677801/
https://www.ncbi.nlm.nih.gov/pubmed/31375681
http://dx.doi.org/10.1038/s41467-019-11412-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677801/
https://www.ncbi.nlm.nih.gov/pubmed/31375681
http://dx.doi.org/10.1038/s41467-019-11412-5

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