A Novel Cell-Penetrating Antibody Fragment Inhibits the DNA Repair Protein RAD51

DNA damaging chemotherapies are successful in cancer therapy, however, the damage can be reversed by DNA repair mechanisms that may be up-regulated in cancer cells. We hypothesized that inhibiting RAD51, a protein involved in homologous recombination DNA repair, would block DNA repair and restore th...

Descripción completa

Detalles Bibliográficos
Autores principales: Pastushok, Landon, Fu, Yongpeng, Lin, Leo, Luo, Yu, DeCoteau, John F., Lee, Ken, Geyer, C. Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677837/
https://www.ncbi.nlm.nih.gov/pubmed/31375703
http://dx.doi.org/10.1038/s41598-019-47600-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677837/
https://www.ncbi.nlm.nih.gov/pubmed/31375703
http://dx.doi.org/10.1038/s41598-019-47600-y

Ejemplares similares