Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival

Background: Natural killer (NK) cells are potential effectors in anti-cancer immunotherapy; however only a subset potently kills cancer cells. Here, we examined whether pretreatment of glioblastoma (GBM) with the proteasome inhibitor, bortezomib (BTZ), might sensitize tumour cells to NK cell lysis b...

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Detalles Bibliográficos
Autores principales: Gras Navarro, Andrea, Espedal, Heidi, Joseph, Justin Vareecal, Trachsel-Moncho, Laura, Bahador, Marzieh, Tore Gjertsen, Bjørn, Klæboe Kristoffersen, Einar, Simonsen, Anne, Miletic, Hrvoje, Øyvind Enger, Per, Rahman, Mohummad Aminur, Chekenya, Martha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678126/
https://www.ncbi.nlm.nih.gov/pubmed/31319548
http://dx.doi.org/10.3390/cancers11070996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678126/
https://www.ncbi.nlm.nih.gov/pubmed/31319548
http://dx.doi.org/10.3390/cancers11070996

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