Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation

Activation of the nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome cascade has a role in the pathogenesis of ischemia/reperfusion (IR) injury. There is growing evidence indicating cytochrome p450 (CYP450)-derived metabolites of n-3 a...

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Detalles Bibliográficos
Autores principales: Darwesh, Ahmed M., Keshavarz-Bahaghighat, Hedieh, Jamieson, K. Lockhart, Seubert, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678157/
https://www.ncbi.nlm.nih.gov/pubmed/31319469
http://dx.doi.org/10.3390/ijms20143502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678157/
https://www.ncbi.nlm.nih.gov/pubmed/31319469
http://dx.doi.org/10.3390/ijms20143502

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