Cargando…

Molecular Mechanisms of p63-Mediated Squamous Cancer Pathogenesis

The p63 gene is a member of the p53/p63/p73 family of transcription factors and plays a critical role in development and homeostasis of squamous epithelium. p63 is transcribed as multiple isoforms; ΔNp63α, the predominant p63 isoform in stratified squamous epithelium, is localized to the basal cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moses, Michael A., George, Andrea L., Sakakibara, Nozomi, Mahmood, Kanwal, Ponnamperuma, Roshini M., King, Kathryn E., Weinberg, Wendy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678256/ https://www.ncbi.nlm.nih.gov/pubmed/31340447 http://dx.doi.org/10.3390/ijms20143590

Ejemplares similares

Oncogenic Ras and ΔNp63α cooperate to recruit immunosuppressive polymorphonuclear myeloid-derived suppressor cells in a mouse model of squamous cancer pathogenesis
por: Sakakibara, Nozomi, et al.
Publicado: (2023)

Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63
por: King, Kathryn E., et al.
Publicado: (2013)

Dysregulated ΔNp63α Inhibits Expression of Ink4a/arf, Blocks Senescence, and Promotes Malignant Conversion of Keratinocytes
por: Ha, Linan, et al.
Publicado: (2011)

The Use of P63 Immunohistochemistry for the Identification of Squamous Cell Carcinoma of the Lung
por: Conde, Esther, et al.
Publicado: (2010)

Notch signaling mediates p63-induced quiescence: A new facet of p63/Notch crosstalk
por: Forster, Nicole, et al.
Publicado: (2011)

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma
por: Somerville, Tim D.D., et al.
Publicado: (2018)

Expression of P63, P16 and CK17 in Atypical Squamous Metaplasia and Cervical Intraepithelial Neoplasia
por: Iranpour, Maryam, et al.
Publicado: (2021)

Subdomain-Specific Localization of Climp-63 (P63) in the Endoplasmic Reticulum Is Mediated by Its Luminal α-Helical Segment
por: Klopfenstein, Dieter R., et al.
Publicado: (2001)

Immunohistochemical evaluation of p63 and cyclin D1 in oral squamous cell carcinoma and leukoplakia
por: Patel, Sunit B., et al.
Publicado: (2017)

DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma
por: Strubel, Alexander, et al.
Publicado: (2023)

Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma
por: Minemura, Chikashi, et al.
Publicado: (2022)

DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma
por: Pokorna, Zuzana, et al.
Publicado: (2022)

pVHL Mediates K63-Linked Ubiquitination of nCLU
por: Xue, Jing, et al.
Publicado: (2012)

Pathway Regulation of p63, a Director of Epithelial Cell Fate
por: Yoh, Kathryn, et al.
Publicado: (2015)

p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma
por: Awais, Raheela, et al.
Publicado: (2016)

Greater specificity of p40 compared with p63 in distinguishing squamous cell carcinoma from adenocarcinoma in effusion cellblocks
por: Kim, Nah Ihm, et al.
Publicado: (2020)

The Expressions of Keratins and P63 in Primary Squamous Cell Carcinoma of the Thyroid Gland: An Application of Raman Spectroscopy
por: Wang, Si-si, et al.
Publicado: (2020)

p63 Directs Subtype-Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma
por: Glathar, Alexandra Ruth, et al.
Publicado: (2022)

Repression of Wnt/β-catenin response elements by p63 (TP63)
por: Katoh, Iyoko, et al.
Publicado: (2016)

C-deletion in exon 4 codon 63 of p53 gene as a molecular marker for oral squamous cell carcinoma: A preliminary study
por: Sukhija, Hemani, et al.
Publicado: (2015)

Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis
por: Wang, Jun, et al.
Publicado: (2021)

Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer’s disease
por: Puangmalai, Nicha, et al.
Publicado: (2022)

M.P.S. status report no. 63
por: Schulte, E
Publicado: (1964)

p63 the guardian of human reproduction
por: Amelio, Ivano, et al.
Publicado: (2012)

p63 role in breast cancer
por: Di Franco, Simone, et al.
Publicado: (2016)

The dual role of p63 in cancer
por: Xu, Yongfeng, et al.
Publicado: (2023)

ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development
por: Smirnov, Artem, et al.
Publicado: (2018)

A Systemic and Integrated Analysis of p63-Driven Regulatory Networks in Mouse Oral Squamous Cell Carcinoma
por: Glathar, Alexandra Ruth, et al.
Publicado: (2023)

HDAC inhibitors suppress the proliferation, migration and invasiveness of human head and neck squamous cell carcinoma cells via p63-mediated tight junction molecules and p21-mediated growth arrest
por: Kakiuchi, Akito, et al.
Publicado: (2021)

Structural diversity of p63 and p73 isoforms
por: Osterburg, Christian, et al.
Publicado: (2022)

p63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair
por: Lin, Yu-Li, et al.
Publicado: (2009)

p53, p63 and p73 in the wonderland of S. cerevisiae
por: Billant, Olivier, et al.
Publicado: (2017)

Allele-specific silencing of EEC p63 mutant R304W restores p63 transcriptional activity
por: Novelli, F, et al.
Publicado: (2016)

Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytes
por: Sethi, Isha, et al.
Publicado: (2014)

Molecular Deregulation of EPAS1 in the Pathogenesis of Esophageal Squamous Cell Carcinoma
por: Islam, Farhadul, et al.
Publicado: (2020)

Pathogenesis of Penile Squamous Cell Carcinoma: Molecular Update and Systematic Review
por: Ribera-Cortada, Inmaculada, et al.
Publicado: (2021)

Wilms’ tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck
por: Li, Xingru, et al.
Publicado: (2015)

Dysregulation of junctional adhesion molecule-A via p63/GATA-3 in head and neck squamous cell carcinoma
por: Kakuki, Takuya, et al.
Publicado: (2016)

p63(+)Krt5(+) basal cells are increased in the squamous metaplastic epithelium of patients with radiation-induced chronic Rhinosinusitis
por: Huang, Hongming, et al.
Publicado: (2020)

Transcriptional Network of p63 in Human Keratinocytes
por: Pozzi, Silvia, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_8h3k10ouspldnkultg09vd5o8l