Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor

About 95% of patients with Glioblastoma (GBM) show tumor relapse, leaving them with limited therapeutic options as recurrent tumors are most often resistant to the first line chemotherapy standard Temozolomide (TMZ). To identify molecular pathways involved in TMZ resistance, primary GBM Stem-like Ce...

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Detalles Bibliográficos
Autores principales: Hannen, Ricarda, Selmansberger, Martin, Hauswald, Maria, Pagenstecher, Axel, Nist, Andrea, Stiewe, Thorsten, Acker, Till, Carl, Barbara, Nimsky, Christopher, Bartsch, Jörg Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678269/
https://www.ncbi.nlm.nih.gov/pubmed/31262047
http://dx.doi.org/10.3390/cancers11070921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678269/
https://www.ncbi.nlm.nih.gov/pubmed/31262047
http://dx.doi.org/10.3390/cancers11070921

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