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Heightened JNK Activation and Reduced XIAP Levels Promote TRAIL and Sunitinib-Mediated Apoptosis in Colon Cancer Models

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis that may be a promising agent in cancer therapy due to its selectivity toward tumor cells. However, many cancer cells are resistant to TRAIL due to defects in apoptosis signaling or activation of surviva...

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Detalles Bibliográficos
Autores principales:	Mahalingam, Devalingam, Carew, Jennifer S., Espitia, Claudia M., Cool, Robbert H., Giles, Francis J., de Jong, Steven, Nawrocki, Steffan T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678293/ https://www.ncbi.nlm.nih.gov/pubmed/31248045 http://dx.doi.org/10.3390/cancers11070895

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