Helping the Released Guardian: Drug Combinations for Supporting the Anticancer Activity of HDM2 (MDM2) Antagonists

The protein p53, known as the “Guardian of the Genome”, plays an important role in maintaining DNA integrity, providing protection against cancer-promoting mutations. Dysfunction of p53 is observed in almost every cancer, with 50% of cases bearing loss-of-function mutations/deletions in the TP53 gen...

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Detalles Bibliográficos
Autores principales: Kocik, Justyna, Machula, Monika, Wisniewska, Aneta, Surmiak, Ewa, Holak, Tad A., Skalniak, Lukasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678622/
https://www.ncbi.nlm.nih.gov/pubmed/31331108
http://dx.doi.org/10.3390/cancers11071014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678622/
https://www.ncbi.nlm.nih.gov/pubmed/31331108
http://dx.doi.org/10.3390/cancers11071014

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