Intrinsic Resistance to EGFR-Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small Cell Lung Cancer: Differences and Similarities with Acquired Resistance

Activating mutations in the epidermal growth factor receptor gene occur as early cancer-driving clonal events in a subset of patients with non-small cell lung cancer (NSCLC) and result in increased sensitivity to EGFR-tyrosine-kinase-inhibitors (EGFR-TKIs). Despite very frequent and often prolonged...

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Detalles Bibliográficos
Autores principales: Santoni-Rugiu, Eric, Melchior, Linea C., Urbanska, Edyta M., Jakobsen, Jan N., de Stricker, Karin, Grauslund, Morten, Sørensen, Jens B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678669/
https://www.ncbi.nlm.nih.gov/pubmed/31266248
http://dx.doi.org/10.3390/cancers11070923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678669/
https://www.ncbi.nlm.nih.gov/pubmed/31266248
http://dx.doi.org/10.3390/cancers11070923

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