Cargando…

Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder. It is mainly caused by mutations in genes encoding sarcomere proteins. Mutant forms of these highly abundant proteins likely stress the protein quality control (PQC) system of cardiomyocytes. The PQC system, together wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dorsch, Larissa M., Schuldt, Maike, dos Remedios, Cristobal G., Schinkel, Arend F. L., de Jong, Peter L., Michels, Michelle, Kuster, Diederik W. D., Brundel, Bianca J. J. M., van der Velden, Jolanda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678711/ https://www.ncbi.nlm.nih.gov/pubmed/31323898 http://dx.doi.org/10.3390/cells8070741

Ejemplares similares

Sex-Related Differences in Protein Expression in Sarcomere Mutation-Positive Hypertrophic Cardiomyopathy
por: Schuldt, Maike, et al.
Publicado: (2021)

Untying the knot: protein quality control in inherited cardiomyopathies
por: Dorsch, Larissa M., et al.
Publicado: (2018)

Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy
por: Nijenkamp, Louise L. A. M., et al.
Publicado: (2020)

The microtubule signature in cardiac disease: etiology, disease stage, and age dependency
por: Algül, Sıla, et al.
Publicado: (2023)

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy
por: Schuldt, Maike, et al.
Publicado: (2021)

Distinct Metabolomic Signatures in Preclinical and Obstructive Hypertrophic Cardiomyopathy
por: Schuldt, Maike, et al.
Publicado: (2021)

Prognostic significance of anterior mitral valve leaflet length in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes
por: van Velzen, Hannah G., et al.
Publicado: (2018)

Unraveling the Genotype‐Phenotype Relationship in Hypertrophic Cardiomyopathy: Obesity‐Related Cardiac Defects as a Major Disease Modifier
por: Nollet, Edgar E., et al.
Publicado: (2020)

Genotype‐specific pathogenic effects in human dilated cardiomyopathy
por: Bollen, Ilse A. E., et al.
Publicado: (2017)

Transcriptional bursts and heterogeneity among cardiomyocytes in hypertrophic cardiomyopathy
por: Burkart, Valentin, et al.
Publicado: (2022)

Left-ventricular outflow tract acceleration time is associated with symptoms in patients with obstructive hypertrophic cardiomyopathy
por: Huurman, Roy, et al.
Publicado: (2020)

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy
por: McNamara, James W., et al.
Publicado: (2017)

Scientists on the spot: Relaxing the heart in hypertrophic cardiomyopathy
por: Gladka, Monika M, et al.
Publicado: (2023)

Five-year prognostic significance of global longitudinal strain in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes
por: van Velzen, H. G., et al.
Publicado: (2019)

Peripartum cardiomyopathy and dilated cardiomyopathy: different at heart
por: Bollen, Ilse A. E., et al.
Publicado: (2015)

Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation
por: Lynch, Thomas L., et al.
Publicado: (2015)

Contemporary family screening in hypertrophic cardiomyopathy: the role of cardiovascular magnetic resonance( )
por: Huurman, Roy, et al.
Publicado: (2022)

Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration
por: Nollet, Edgar E, et al.
Publicado: (2023)

Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy
por: Montag, Judith, et al.
Publicado: (2017)

Three-dimensional echocardiography for the assessment of left ventricular geometry and papillary muscle morphology in hypertrophic cardiomyopathy
por: Erden, Mustafa, et al.
Publicado: (2018)

Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes
por: Schuldt, Maike, et al.
Publicado: (2021)

Strength of patient cohorts and biobanks for cardiomyopathy research
por: de Boer, R. A., et al.
Publicado: (2020)

Novel Morphological Features on CMR for the Prediction of Pathogenic Sarcomere Gene Variants in Subjects Without Hypertrophic Cardiomyopathy
por: van der Velde, Nikki, et al.
Publicado: (2021)

T-tubule remodeling in human hypertrophic cardiomyopathy
por: Vitale, Giulia, et al.
Publicado: (2020)

Prognostic significance of left atrial strain in sarcomere gene variant carriers without hypertrophic cardiomyopathy
por: Huurman, Roy, et al.
Publicado: (2022)

Increased Myocardial Oxygen Consumption Precedes Contractile Dysfunction in Hypertrophic Cardiomyopathy Caused by Pathogenic TNNT2 Gene Variants
por: Parbhudayal, Rahana Y., et al.
Publicado: (2020)

Blood‐based biomarkers for the prediction of hypertrophic cardiomyopathy prognosis: a systematic review and meta‐analysis
por: Jansen, Mark, et al.
Publicado: (2022)

Life-long tailoring of management for patients with hypertrophic cardiomyopathy: Awareness and decision-making in changing scenarios
por: Michels, M., et al.
Publicado: (2016)

Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy
por: Montag, Judith, et al.
Publicado: (2018)

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations
por: Pei, J., et al.
Publicado: (2021)

Translational investigation of electrophysiology in hypertrophic cardiomyopathy
por: Flenner, Frederik, et al.
Publicado: (2021)

Effect of body surface area and gender on wall thickness thresholds in hypertrophic cardiomyopathy
por: Huurman, R., et al.
Publicado: (2019)

Left atrial remodeling and mechanical dysfunction in hypertrophic cardiomyopathy
por: Kim, Kyung-Jin, et al.
Publicado: (2016)

Mitral valve remodeling in the development of obstructive hypertrophic cardiomyopathy
por: Moroni, Francesco, et al.
Publicado: (2023)

Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy
por: Bollen, Ilse A. E., et al.
Publicado: (2017)

FHL2 expression and variants in hypertrophic cardiomyopathy
por: Friedrich, Felix W., et al.
Publicado: (2014)

Untargeted Metabolomics Identifies Potential Hypertrophic Cardiomyopathy Biomarkers in Carriers of MYBPC3 Founder Variants
por: Jansen, Mark, et al.
Publicado: (2023)

Myocardial adaptation after surgical therapy differs for aortic valve stenosis and hypertrophic obstructive cardiomyopathy
por: Parbhudayal, Rahana Y., et al.
Publicado: (2019)

The effect of inhibition of the Na(+)/H(+) exchanger on the development of hypertrophy in hypertrophic cardiomyopathy
por: Brouwer, Wessel P, et al.
Publicado: (2011)

Left ventricular remodeling in hypertrophic cardiomyopathy patients with atrial fibrillation
por: Tian, Hongwei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_d3fe4gid1p1e34vkchgvcrhvms