Novel Silyl Ether-Based Acid-Cleavable Antibody-MMAE Conjugates with Appropriate Stability and Efficacy

Antibody-drug conjugate (ADC) is a novel efficient drug delivery system that has been successfully used in clinical practice, and it has become a research hotspot in the anti-tumor drug field. Acid-cleavable linkers were first used in clinical ADCs, but their structural variety (e.g., hydrazone and...

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Detalles Bibliográficos
Autores principales: Wang, Yanming, Fan, Shiyong, Xiao, Dian, Xie, Fei, Li, Wei, Zhong, Wu, Zhou, Xinbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678733/
https://www.ncbi.nlm.nih.gov/pubmed/31288450
http://dx.doi.org/10.3390/cancers11070957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678733/
https://www.ncbi.nlm.nih.gov/pubmed/31288450
http://dx.doi.org/10.3390/cancers11070957

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