6-Thioguanine and Its Analogs Promote Apoptosis of Castration-Resistant Prostate Cancer Cells in a BRCA2-Dependent Manner

Background: Mutations in the oncosuppressor gene BReast CAncer susceptibility gene 2 (BRCA2) predispose to aggressive forms of prostate cancer which show poor response to taxane-based therapy, the standard treatment for castration-resistant, aggressive prostate cancer. Herein, we addressed the quest...

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Detalles Bibliográficos
Autores principales: Laera, Luna, Guaragnella, Nicoletta, Giannattasio, Sergio, Moro, Loredana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678799/
https://www.ncbi.nlm.nih.gov/pubmed/31284411
http://dx.doi.org/10.3390/cancers11070945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678799/
https://www.ncbi.nlm.nih.gov/pubmed/31284411
http://dx.doi.org/10.3390/cancers11070945

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