Cargando…

6-Thioguanine and Its Analogs Promote Apoptosis of Castration-Resistant Prostate Cancer Cells in a BRCA2-Dependent Manner

Background: Mutations in the oncosuppressor gene BReast CAncer susceptibility gene 2 (BRCA2) predispose to aggressive forms of prostate cancer which show poor response to taxane-based therapy, the standard treatment for castration-resistant, aggressive prostate cancer. Herein, we addressed the quest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Laera, Luna, Guaragnella, Nicoletta, Giannattasio, Sergio, Moro, Loredana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678799/ https://www.ncbi.nlm.nih.gov/pubmed/31284411 http://dx.doi.org/10.3390/cancers11070945

Ejemplares similares

The transcription factors ADR1 or CAT8 are required for RTG pathway activation and evasion from yeast acetic acid-induced programmed cell death in raffinose
por: Laera, Luna, et al.
Publicado: (2016)

Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer
por: Guerra, Flora, et al.
Publicado: (2017)

Molecular mechanisms of Saccharomyces cerevisiae stress adaptation and programmed cell death in response to acetic acid
por: Giannattasio, Sergio, et al.
Publicado: (2013)

Yeast as a Model to Unravel New BRCA2 Functions in Cell Metabolism
por: Costanza, Alessandra, et al.
Publicado: (2022)

Yeast as a Tool to Study Signaling Pathways in Mitochondrial Stress Response and Cytoprotection
por: Ždralević, Maša, et al.
Publicado: (2012)

Acid Stress Triggers Resistance to Acetic Acid-Induced Regulated Cell Death through Hog1 Activation Which Requires RTG2 in Yeast
por: Guaragnella, Nicoletta, et al.
Publicado: (2019)

BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine
por: Gu, Yuexi, et al.
Publicado: (2016)

Effect of 6-thioguanine on the stability of duplex DNA
por: Bohon, Jen, et al.
Publicado: (2005)

RTG Signaling Sustains Mitochondrial Respiratory Capacity in HOG1-Dependent Osmoadaptation
por: Guaragnella, Nicoletta, et al.
Publicado: (2021)

Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine
por: Bayoumy, Ahmed B., et al.
Publicado: (2021)

The role of mitochondria in yeast programmed cell death
por: Guaragnella, Nicoletta, et al.
Publicado: (2012)

BRCA1 regulates PIG3-mediated apoptosis in a p53-dependent manner
por: Zhang, Wenwen, et al.
Publicado: (2015)

Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione
por: Ono, Akira, et al.
Publicado: (2019)

Effects of Abiraterone Acetate on Chronic Kidney Disease in 2 Patients With Metastatic Castration-resistant Prostate Cancer
por: Francini, Edoardo, et al.
Publicado: (2014)

Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration
por: Abida, Wassim, et al.
Publicado: (2020)

6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine
por: Price, D. J., et al.
Publicado: (1971)

In vitro replication and thermodynamic studies of methylation and oxidation modifications of 6-thioguanine
por: Gu, Chunang, et al.
Publicado: (2007)

Utility of Maternal 6-Thioguanine Nucleotide Levels in Predicting Neonatal Pancytopenia
por: Maruyama, Hidehiko, et al.
Publicado: (2012)

MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation
por: Grasso, Francesca, et al.
Publicado: (2014)

6-Thioguanine Inhibits Herpes Simplex Virus 1 Infection of Eyes
por: Chen, Deyan, et al.
Publicado: (2021)

New perspectives from South-Y-East, not all about death. A report of the 12(th) lnternational Meeting on Yeast Apoptosis in Bari, Italy, May 14th-18th, 2017
por: Guaragnella, Nicoletta, et al.
Publicado: (2018)

The first cases of collagenous sprue successfully treated with thioguanine
por: van Gils, Tom, et al.
Publicado: (2016)

Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway
por: Zhang, Daoyu, et al.
Publicado: (2020)

Cyclohexanone curcumin analogs inhibit the progression of castration‐resistant prostate cancer in vitro and in vivo
por: Mapoung, Sariya, et al.
Publicado: (2018)

Toxicity and Clinical Trial of Azaserine and 6-Thioguanine in Advanced Solid Malignant Neoplasms
por: Schroeder, J. M., et al.
Publicado: (1964)

6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro
por: Swaim, Caleb D., et al.
Publicado: (2021)

Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?
por: Lennard, L., et al.
Publicado: (1993)

Quantification of thioguanine-resistant lymphocytes from mice irradiated in vivo.
por: Lorenz, R, et al.
Publicado: (1990)

New therapies for relapsed castration-resistant prostate cancer based on peptide analogs of hypothalamic hormones
por: Schally, Andrew V, et al.
Publicado: (2015)

Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA
por: Gueranger, Quentin, et al.
Publicado: (2011)

Effect of cisplatin on metastatic castration-resistant prostate cancer with BRCA2 mutation: A case report
por: Koguchi, Dai, et al.
Publicado: (2021)

Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and BRCA1, BRCA2, or ATM Alterations Identified by Testing Circulating Tumor DNA
por: Matsubara, Nobuaki, et al.
Publicado: (2023)

Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review
por: Meijer, Berrie, et al.
Publicado: (2016)

Exposure to Thioguanine During 117 Pregnancies in Women With Inflammatory Bowel Disease
por: Crouwel, Femke, et al.
Publicado: (2022)

Identification of castration-dependent and -independent driver genes and pathways in castration-resistant prostate cancer (CRPC)
por: Li, Yan, et al.
Publicado: (2022)

Nelfinavir and Nelfinavir Analogs Block Site-2 Protease Cleavage to Inhibit Castration-Resistant Prostate Cancer
por: Guan, Min, et al.
Publicado: (2015)

Interaction of 6-thioguanine and cytosine arabinoside in cultured cells from patients with acute myeloid leukaemia.
por: Robins, A. B.
Publicado: (1978)

Measurements of 6-thioguanine nucleotide levels with TPMT and NUDT15 genotyping in patients with Crohn’s disease
por: Lee, Ji Hyeon, et al.
Publicado: (2017)

6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2
por: Chuang, Shang-Ju, et al.
Publicado: (2018)

6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities
por: Swaim, Caleb D., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_if0g2ut4hi08fsv4b5rj9k4hlo