Cargando…

Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells

Human intestinal organoids (hIOs), which resemble the human intestine structurally and physiologically, have emerged as a new modality for the study of the molecular and cellular biology of the intestine in vitro. We recently developed an in vitro maturation technique for generating functional hIOs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jung, Kwang Bo, Kwon, Ohman, Lee, Mi-Ok, Lee, Hana, Son, Ye Seul, Habib, Omer, Oh, Jung-Hwa, Cho, Hyun-Soo, Jung, Cho-Rok, Kim, Janghwan, Son, Mi-Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678857/ https://www.ncbi.nlm.nih.gov/pubmed/31277507 http://dx.doi.org/10.3390/jcm8070976

Ejemplares similares

Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
por: Jung, Kwang Bo, et al.
Publicado: (2018)

Comparative analysis of human embryonic stem cell-derived neural stem cells as an in vitro human model
por: Oh, Jung-Hwa, et al.
Publicado: (2018)

Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
por: Lee, Mi-Ok, et al.
Publicado: (2021)

Limosilactobacillus reuteri DS0384 promotes intestinal epithelial maturation via the postbiotic effect in human intestinal organoids and infant mice
por: Lee, Hana, et al.
Publicado: (2022)

Next-Generation Intestinal Toxicity Model of Human Embryonic Stem Cell-Derived Enterocyte-Like Cells
por: Ryu, Bokyeong, et al.
Publicado: (2021)

Low-dose interleukin-2 alleviates dextran sodium sulfate-induced colitis in mice by recovering intestinal integrity and inhibiting AKT-dependent pathways
por: Lee, Hana, et al.
Publicado: (2020)

Generation of Highly Expandable Intestinal Spheroids Composed of Stem Cells
por: Kwon, Ohman, et al.
Publicado: (2022)

Efficient exogenous DNA-free reprogramming with suicide gene vectors
por: Lee, Minhyung, et al.
Publicado: (2019)

Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer
por: Kim, Kwangkho, et al.
Publicado: (2019)

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells
por: Woo, Sun-Mi, et al.
Publicado: (2009)

Current Challenges Associated with the Use of Human Induced Pluripotent Stem Cell-Derived Organoids in Regenerative Medicine
por: Lee, Hana, et al.
Publicado: (2021)

Simplified Brain Organoids for Rapid and Robust Modeling of Brain Disease
por: Ha, Jeongmin, et al.
Publicado: (2020)

A liver‐specific gene expression panel predicts the differentiation status of in vitro hepatocyte models
por: Kim, Dae‐Soo, et al.
Publicado: (2017)

Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells
por: Lee, Mi-Ok, et al.
Publicado: (2019)

Intestinal Morphogenesis in Development, Regeneration, and Disease: The Potential Utility of Intestinal Organoids for Studying Compartmentalization of the Crypt-Villus Structure
por: Kwon, Ohman, et al.
Publicado: (2020)

Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease
por: Son, Mi-Young, et al.
Publicado: (2016)

Gut metabolite trimethylamine N-oxide induces aging-associated phenotype of midbrain organoids for the induced pluripotent stem cell-based modeling of late-onset disease
por: Lee, Youngsun, et al.
Publicado: (2022)

Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer
por: Ryu, Tae Young, et al.
Publicado: (2022)

EHMT1 knockdown induces apoptosis and cell cycle arrest in lung cancer cells by increasing CDKN1A expression
por: Lee, Jinkwon, et al.
Publicado: (2021)

Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC
por: Ryu, Jea-Woon, et al.
Publicado: (2017)

Particulate matter 10 exposure affects intestinal functionality in both inflamed 2D intestinal epithelial cell and 3D intestinal organoid models
por: Son, Ye Seul, et al.
Publicado: (2023)

ARL6IP1 gene delivery reduces neuroinflammation and neurodegenerative pathology in hereditary spastic paraplegia model
por: Lim, Jung Hwa, et al.
Publicado: (2023)

SETDB1 regulates SMAD7 expression for breast cancer metastasis
por: Ryu, Tae Young, et al.
Publicado: (2019)

Upregulation of the JAK-STAT pathway promotes maturation of human embryonic stem cell-derived cardiomyocytes
por: Ho, Beatrice Xuan, et al.
Publicado: (2021)

Kidney Decellularized Extracellular Matrix Enhanced the Vascularization and Maturation of Human Kidney Organoids
por: Kim, Jin Won, et al.
Publicado: (2022)

Combined Influence of Depression and Physical Frailty on Cognitive Impairment in Patients with Heart Failure
por: Lee, Jong Kyung, et al.
Publicado: (2018)

The influence of positive end-expiratory pressure (PEEP) in predicting fluid responsiveness in patients undergoing one-lung ventilation
por: Jun, In-Jung, et al.
Publicado: (2021)

The novel prognostic marker, EHMT2, is involved in cell proliferation via HSPD1 regulation in breast cancer
por: Kim, Seon-Kyu, et al.
Publicado: (2018)

Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson’s Disease
por: Sim, Hyuna, et al.
Publicado: (2020)

EGCG Attenuates Autoimmune Arthritis by Inhibition of STAT3 and HIF-1α with Th17/Treg Control
por: Yang, Eun-Ji, et al.
Publicado: (2014)

Modeling Pancreatic Cancer with Patient-Derived Organoids Integrating Cancer-Associated Fibroblasts
por: Go, Yoon-Ha, et al.
Publicado: (2022)

Development and evaluation of next-generation cardiotoxicity assay based on embryonic stem cell-derived cardiomyocytes
por: Ryu, Bokyeong, et al.
Publicado: (2020)

The proliferative and multipotent epidermal progenitor cells for human skin reconstruction in vitro and in vivo
por: Lim, Jung Hwa, et al.
Publicado: (2022)

Direct Effect of Chenodeoxycholic Acid on Differentiation of Mouse Embryonic Stem Cells Cultured under Feeder-Free Culture Conditions
por: Park, Soon-Jung, et al.
Publicado: (2013)

IL-1 Receptor Blockade Alleviates Graft-versus-Host Disease through Downregulation of an Interleukin-1β-Dependent Glycolytic Pathway in Th17 Cells
por: Park, Min-Jung, et al.
Publicado: (2015)

Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies
por: Kang, Hyun Mi, et al.
Publicado: (2019)

Clinicopathologic implication of PD-L1 and phosphorylated STAT3 expression in diffuse large B cell lymphoma
por: Kwon, Hyun Jung, et al.
Publicado: (2018)

Enhanced Inner-Ear Organoid Formation from Mouse Embryonic Stem Cells by Photobiomodulation
por: Chang, So-Young, et al.
Publicado: (2020)

Erratum: US-Guided Radiofrequency Ablation for Low-Risk Papillary Thyroid Microcarcinoma: Efficacy and Safety in a Large Population
por: Lim, Hyun Kyung, et al.
Publicado: (2020)

US-Guided Radiofrequency Ablation for Low-Risk Papillary Thyroid Microcarcinoma: Efficacy and Safety in a Large Population
por: Lim, Hyun Kyung, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cfbt9d2mk1rs5d0hkpvgf8cf47