Molecular Mode of Action of TRAIL Receptor Agonists—Common Principles and Their Translational Exploitation

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its death receptors TRAILR1/death receptor 4 (DR4) and TRAILR2/DR5 trigger cell death in many cancer cells but rarely exert cytotoxic activity on non-transformed cells. Against this background, a variety of recombinant TRAIL variant...

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Detalles Bibliográficos
Autor principal: Wajant, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678900/
https://www.ncbi.nlm.nih.gov/pubmed/31284696
http://dx.doi.org/10.3390/cancers11070954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678900/
https://www.ncbi.nlm.nih.gov/pubmed/31284696
http://dx.doi.org/10.3390/cancers11070954

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