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Molecular Mode of Action of TRAIL Receptor Agonists—Common Principles and Their Translational Exploitation
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its death receptors TRAILR1/death receptor 4 (DR4) and TRAILR2/DR5 trigger cell death in many cancer cells but rarely exert cytotoxic activity on non-transformed cells. Against this background, a variety of recombinant TRAIL variant...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678900/ https://www.ncbi.nlm.nih.gov/pubmed/31284696 http://dx.doi.org/10.3390/cancers11070954 |