Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping

Here we show that the serine/arginine rich splicing factor 2 (SRSF2) promotes cryptic 3′ splice-site (3′AG′) usage during cassette exon exclusion in survival of motor neuron (SMN2) minigenes. Deletion of the 3′AG′ (3′AG′1), its associated branch point (BP′) and polypyrimidine tract (PPT′) sequences...

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Detalles Bibliográficos
Autores principales: Moon, Heegyum, Jang, Ha Na, Liu, Yongchao, Choi, Namjeong, Oh, Jagyeong, Ha, Jiyeon, Zheng, Xuexiu, Shen, Haihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678912/
https://www.ncbi.nlm.nih.gov/pubmed/31295920
http://dx.doi.org/10.3390/cells8070696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678912/
https://www.ncbi.nlm.nih.gov/pubmed/31295920
http://dx.doi.org/10.3390/cells8070696

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