Brexpiprazole, a Serotonin-Dopamine Activity Modulator, Can Sensitize Glioma Stem Cells to Osimertinib, a Third-Generation EGFR-TKI, via Survivin Reduction

Glioblastoma is a primary brain tumor associated with a poor prognosis due to its high chemoresistance capacity. Cancer stem cells (CSCs) are one of the mechanisms of chemoresistance. Although therapy targeting CSCs is promising, strategies targeting CSCs remain unsuccessful. Abnormal activation of...

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Detalles Bibliográficos
Autores principales: Suzuki, Shuhei, Yamamoto, Masahiro, Sanomachi, Tomomi, Togashi, Keita, Sugai, Asuka, Seino, Shizuka, Yoshioka, Takashi, Kitanaka, Chifumi, Okada, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679129/
https://www.ncbi.nlm.nih.gov/pubmed/31284441
http://dx.doi.org/10.3390/cancers11070947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679129/
https://www.ncbi.nlm.nih.gov/pubmed/31284441
http://dx.doi.org/10.3390/cancers11070947

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