Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1

Clinical use of the anti-cancer drug doxorubicin (DOX) is largely limited due to its severe cardiotoxicity. Dysregulation of autophagy is implicated in DOX-induced cardiotoxicity (DIC). Prior studies have indicated that Beclin1 and lysosomal-associated membrane proteins-1 (LAMP1) are critical mediat...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoping, Li, Chun, Wang, Qiyan, Li, Weili, Guo, Dongqing, Zhang, Xuefeng, Shao, Mingyan, Chen, Xu, Ma, Lin, Zhang, Qian, Wang, Wei, Wang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679133/
https://www.ncbi.nlm.nih.gov/pubmed/31261758
http://dx.doi.org/10.3390/cancers11070910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679133/
https://www.ncbi.nlm.nih.gov/pubmed/31261758
http://dx.doi.org/10.3390/cancers11070910

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