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Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy

In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck-deficient T-cell lines have shown that Lck regulates the initiation of TCR signaling, T-cell development, and T-cell hom...

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Detalles Bibliográficos
Autores principales: Bommhardt, Ursula, Schraven, Burkhart, Simeoni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679228/
https://www.ncbi.nlm.nih.gov/pubmed/31315298
http://dx.doi.org/10.3390/ijms20143500