The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor

The Wnt gene family encodes an evolutionarily conserved group of proteins that regulate cell growth, differentiation and stem cell self-renewal. Aberrant Wnt signaling in human breast tumors has been proposed as a driver of tumorigenesis, especially in the basal-like tumor subtype where canonical Wn...

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Detalles Bibliográficos
Autores principales: Pfefferle, Adam D., Darr, David B., Calhoun, Benjamin C., Mott, Kevin R., Rosen, Jeffrey M., Perou, Charles M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679375/
https://www.ncbi.nlm.nih.gov/pubmed/31213486
http://dx.doi.org/10.1242/dmm.037192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679375/
https://www.ncbi.nlm.nih.gov/pubmed/31213486
http://dx.doi.org/10.1242/dmm.037192

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