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Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity
BACKGROUND: MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers. A plethora of drugs were developed to block this kinase pathway for clinical application. With the exc...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679490/ https://www.ncbi.nlm.nih.gov/pubmed/31375085 http://dx.doi.org/10.1186/s12885-019-5914-8 |