The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

The receptor-interacting protein 1 (RIPK1)/RIPK3 kinases play important roles in necroptosis that is closely linked to inflammatory response. Although the activation of necroptosis is well characterized, how necroptosis is tuned down is largely unknown. Here, we found that Parkin (also known as PARK...

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Detalles Bibliográficos
Autores principales: Lee, Seung Baek, Kim, Jung Jin, Han, Sang-Ah, Fan, Yingfang, Guo, Li-Sha, Aziz, Khaled, Nowsheen, Somaira, Kim, Sung Sun, Park, Seon-Young, Luo, Qifeng, Chung, Jin Ook, Choi, Sung Il, Aziz, Asef, Yin, Ping, Tong, Seo-Yun, Fiesel, Fabienne C., Springer, Wolfdieter, Zhang, Jin-San, Lou, Zhenkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679774/
https://www.ncbi.nlm.nih.gov/pubmed/31358971
http://dx.doi.org/10.1038/s41556-019-0356-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679774/
https://www.ncbi.nlm.nih.gov/pubmed/31358971
http://dx.doi.org/10.1038/s41556-019-0356-8

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