Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants

Mutations and inadequate methylation profiles of CITED2 are associated with human congenital heart disease (CHD). In mouse, Cited2 is necessary for embryogenesis, particularly for heart development, and its depletion in embryonic stem cells (ESC) impairs cardiac differentiation. We have now determin...

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Detalles Bibliográficos
Autores principales: Santos, João M. A., Mendes-Silva, Leonardo, Afonso, Vanessa, Martins, Gil, Machado, Rui S. R., Lopes, João A., Cancela, Leonor, Futschik, Matthias E., Sachinidis, Agapios, Gavaia, Paulo, Bragança, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680046/
https://www.ncbi.nlm.nih.gov/pubmed/31378782
http://dx.doi.org/10.1038/s41419-019-1816-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680046/
https://www.ncbi.nlm.nih.gov/pubmed/31378782
http://dx.doi.org/10.1038/s41419-019-1816-6

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