Abrogation of store-operated Ca(2+) entry protects against crystal-induced ER stress in human proximal tubular cells

Calcium crystal internalization into proximal tubular (PT) cells results in acute kidney injury, nephrocalcinosis, chronic kidney disease (CKD), and kidney-stone formation. Ca(2+) supersaturation in PT luminal fluid induces calcium crystal formation, leading to aberrant crystal internalization into...

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Detalles Bibliográficos
Autores principales: Gombedza, Farai C., Shin, Samuel, Kanaras, Yianni L., Bandyopadhyay, Bidhan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680047/
https://www.ncbi.nlm.nih.gov/pubmed/31396401
http://dx.doi.org/10.1038/s41420-019-0203-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680047/
https://www.ncbi.nlm.nih.gov/pubmed/31396401
http://dx.doi.org/10.1038/s41420-019-0203-5

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