VE-822 mediated inhibition of ATR signaling sensitizes chondrosarcoma to cisplatin via reversion of the DNA damage response

INTRODUCTION: Cisplatin has been reported to elicit the DNA damage response (DDR) via activation of the ATR-Chk1 pathway, which in turn contributes to the induction of cisplatin resistance. Inhibition of ATR-Chk1 signaling reverses cisplatin resistance in some cancers. However, the influence of inhi...

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Detalles Bibliográficos
Autores principales: Liang, Xiao, Yang, Qiya, Wang, Wanchun, Liu, Tang, Hu, Jinyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680083/
https://www.ncbi.nlm.nih.gov/pubmed/31839711
http://dx.doi.org/10.2147/OTT.S211560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680083/
https://www.ncbi.nlm.nih.gov/pubmed/31839711
http://dx.doi.org/10.2147/OTT.S211560

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