An Expedient Total Synthesis of Chivosazole F: an Actin‐Binding Antimitotic Macrolide from the Myxobacterium Sorangium Cellulosum

A unified strategy for the chemical synthesis of the chivosazoles is described. This strategy is based on two closely related approaches involving the late‐stage installation of the isomerization‐prone (2Z,4E,6Z,8E)‐tetraenoate motif, and an expedient fragment‐assembly procedure. The result is a hig...

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Detalles Bibliográficos
Autores principales: Williams, Simon, Jin, Jialu, Kan, S. B. Jennifer, Li, Mungyuen, Gibson, Lisa J., Paterson, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680201/
https://www.ncbi.nlm.nih.gov/pubmed/27897365
http://dx.doi.org/10.1002/anie.201610636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680201/
https://www.ncbi.nlm.nih.gov/pubmed/27897365
http://dx.doi.org/10.1002/anie.201610636

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