Cargando…

Synthesis of Pyrrolo[3,4-b]pyridin-5-ones via Multicomponent Reactions and In Vitro–In Silico Studies Against SiHa, HeLa, and CaSki Human Cervical Carcinoma Cell Lines

A series of 12 polysubstituted pyrrolo[3,4-b]pyridin-5-ones were synthesized via a one-pot cascade process (Ugi–3CR/aza Diels-Alder/N-acylation/decarboxylation/dehydration) and studied in vitro using human epithelial cervical carcinoma SiHa, HeLa, and CaSki cell line cultures. Three compounds of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Segura-Olvera, Daniel, García-González, Ailyn N., Morales-Salazar, Ivette, Islas-Jácome, Alejandro, Rojas-Aguirre, Yareli, Ibarra, Ilich A., Díaz-Cervantes, Erik, Alcaraz-Estrada, Sofía Lizeth, González-Zamora, Eduardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680468/ https://www.ncbi.nlm.nih.gov/pubmed/31336585 http://dx.doi.org/10.3390/molecules24142648

Ejemplares similares

Enhancer‐promoter Activity of Human Papillomavirus Type 16 Long Control Regions Isolated from Cell Lines SiHa and CaSki and Cervical Cancer Biopsies
por: Kozuka, Takuyo, et al.
Publicado: (2000)

Differential suppression of the tumorigenicity of HeLa and SiHa cells by adeno-associated virus.
por: Su, P. F., et al.
Publicado: (1996)

Thymoquinone Inhibits the Migration and Invasive Characteristics of Cervical Cancer Cells SiHa and CaSki In Vitro by Targeting Epithelial to Mesenchymal Transition Associated Transcription Factors Twist1 and Zeb1
por: Li, Jun, et al.
Publicado: (2017)

Proteomic datasets of HeLa and SiHa cell lines acquired by DDA-PASEF and diaPASEF
por: Huang, Zelu, et al.
Publicado: (2022)

Pseudo-multicomponent reactions
por: Flores-Reyes, Julio C., et al.
Publicado: (2023)

Cholecalciferol Inhibits Cell Growth and Induces Apoptosis in the CaSki Cell Line
por: Bhoora, Sachin, et al.
Publicado: (2020)

Pharmacological targeting transient receptor potential canonical channel 6 modulates biological behaviors for cervical cancer HeLa and SiHA cell
por: Bai, Li-ping, et al.
Publicado: (2022)

Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway
por: Zhao, Xinwei, et al.
Publicado: (2016)

Synthesis of Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via a One-Pot (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/S(N)2) Process. A Suitable Alternative towards Novel Aza-Analogues of Falipamil
por: Zamudio-Medina, Angel, et al.
Publicado: (2018)

Adherence of Trichomonas vaginalis to SiHa Cells is Inhibited by Diphenyleneiodonium
por: Kim, Yeeun, et al.
Publicado: (2020)

William A. Caskie
Publicado: (1921)

The Aqueous Extract of Ficus religiosa Induces Cell Cycle Arrest in Human Cervical Cancer Cell Lines SiHa (HPV-16 Positive) and Apoptosis in HeLa (HPV-18 Positive)
por: Choudhari, Amit S., et al.
Publicado: (2013)

Trichomonas vaginalis Metalloproteinase Induces mTOR Cleavage of SiHa Cells
por: Quan, Juan-Hua, et al.
Publicado: (2014)

Thymoquinone-Loaded Nanostructured Lipid Carrier Exhibited Cytotoxicity towards Breast Cancer Cell Lines (MDA-MB-231 and MCF-7) and Cervical Cancer Cell Lines (HeLa and SiHa)
por: Ng, Wei Keat, et al.
Publicado: (2015)

Subcellular localization of the human papillomavirus 16 E7 oncoprotein in CaSki cells and its detection in cervical adenocarcinoma and adenocarcinoma in situ
por: Dreier, Kerstin, et al.
Publicado: (2011)

Reduced tumorigenicity and pathogenicity of cervical carcinoma SiHa cells selected for resistance to cidofovir
por: De Schutter, Tim, et al.
Publicado: (2013)

Ferulic Acid Induces Apoptosis of HeLa and Caski Cervical Carcinoma Cells by Down-Regulating the Phosphatidylinositol 3-Kinase (PI3K)/Akt Signaling Pathway
por: Luo, Liping, et al.
Publicado: (2020)

UHRF1 gene silencing inhibits cell proliferation and promotes cell apoptosis in human cervical squamous cell carcinoma CaSki cells
por: Ge, Ting-Ting, et al.
Publicado: (2016)

Green synthesis, structure optimization and biological evalution of Rhopaladins’ analog 2–styryl–5-oxopyrrolidine-2- carboxamide RPDPRH on CaSki cells
por: Ke, Li-Na, et al.
Publicado: (2022)

Hydroxychloroquine facilitates autophagosome formation but not degradation to suppress the proliferation of cervical cancer SiHa cells
por: LIU, QINGSONG, et al.
Publicado: (2014)

Crinamine Induces Apoptosis and Inhibits Proliferation, Migration, and Angiogenesis in Cervical Cancer SiHa Cells
por: Khumkhrong, Phattharachanok, et al.
Publicado: (2019)

P16(INK4A) is required for cisplatin resistance in cervical carcinoma SiHa cells
por: LI, YUERAN, et al.
Publicado: (2015)

Pentoxifylline Inhibits TNF-α/TGF-β1-Induced Epithelial-Mesenchymal Transition via Suppressing the NF-κB Pathway and SERPINE1 Expression in CaSki Cells
por: Palafox-Mariscal, Luis Arturo, et al.
Publicado: (2023)

Cudrania tricuspidata Stem Extract Induces Apoptosis via the Extrinsic Pathway in SiHa Cervical Cancer Cells
por: Kwon, Sae-Bom, et al.
Publicado: (2016)

ARHGAP1 overexpression inhibits proliferation, migration and invasion of C-33A and SiHa cell lines
por: Li, Jun-ping, et al.
Publicado: (2017)

– (-) Menthol Induces Reversal of Promoter Hypermethylation and Associated Up-Regulation of the FANCF Gene in the SiHa Cell Line
por: Parashar, Gaurav, et al.
Publicado: (2017)

Phenolic Compounds from Polygonum chinense Induce Growth Inhibition and Apoptosis of Cervical Cancer SiHa Cells
por: Chen, Wei, et al.
Publicado: (2020)

Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)
por: Mohammed Asik, Rajmohamed, et al.
Publicado: (2021)

Synthesis of Pyrrolo[3,4-b]pyridin-5-ones via Ugi–Zhu Reaction and In Vitro–In Silico Studies against Breast Carcinoma
por: Morales-Salazar, Ivette, et al.
Publicado: (2023)

C-phycocyanin inhibits epithelial-to-mesenchymal transition in Caski cells
por: Ji, Huanhuan, et al.
Publicado: (2020)

Correction: Zhao, X.W., et al. Dioscin Induces the Apoptosis of Human Cervical Carcinoma HeLa and SiHa Cells Through ROS-mediated DNA Damage, Cell Cycle Arrest and Mitochondrial Signaling Pathways. Molecules 2016, 21, 730
por: Zhao, Xinwei, et al.
Publicado: (2020)

Application of HTB-SiHa Cells Transfected with a Recombinant Plasmid for External Quality Assessment of Chlamydia trachomatis PCR
por: Zhang, Kuo, et al.
Publicado: (2014)

Sonoporation efficacy on SiHa cells in vitro at raised bath temperatures—experimental validation of a prototype sonoporation device
por: Kivinen, Jonathan, et al.
Publicado: (2015)

Trichomonas vaginalis Induces SiHa Cell Apoptosis by NF-κB Inactivation via Reactive Oxygen Species
por: Quan, Juan-Hua, et al.
Publicado: (2017)

Synthesis of New Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via an Ugi-Zhu/Cascade/Click Strategy
por: Blanco-Carapia, Roberto E., et al.
Publicado: (2023)

Multicomponent synthesis of some new (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamates and their in vitro anti-proliferative activity against CaSki, MDA-MB-231 and SK-Lu-1 tumour cells as apoptosis inducing agents without necrosis
por: Laskar, Sujay, et al.
Publicado: (2017)

HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells
por: Liang, Feixin, et al.
Publicado: (2011)

Gene silencing of HPV16 E6/E7 induced by promoter-targeting siRNA in SiHa cells
por: Hong, D, et al.
Publicado: (2009)

Quantitative analysis of proteins related to chemoresistance to paclitaxel and carboplatin in human SiHa cervical cancer cells via iTRAQ
por: He, Yue, et al.
Publicado: (2019)

Clinacanthus nutans Standardized Fraction Arrested SiHa Cells at G1/S and Induced Apoptosis via Upregulation of p53
por: Nik Zainuddin, Nik Aina Syazana, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_c51sr6fecdtlo6mipa9sl204nc