Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors

Extracellular acidification is an important feature of tumor microenvironments but has yet to be successfully exploited in cancer therapy. The reversal of the pH gradient across the plasma membrane in cells that regulate intracellular pH (pHi) has potential to drive the selective uptake of weak acid...

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Detalles Bibliográficos
Autores principales: Hay, Michael P., Shin, Hong Nam, Wong, Way Wua, Sahimi, Wan Wan, Vaz, Aaron T.D., Yadav, Pooja, Anderson, Robert F., Hicks, Kevin O., Wilson, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680510/
https://www.ncbi.nlm.nih.gov/pubmed/31295864
http://dx.doi.org/10.3390/molecules24142524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680510/
https://www.ncbi.nlm.nih.gov/pubmed/31295864
http://dx.doi.org/10.3390/molecules24142524

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