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High Impact: The Role of Promiscuous Binding Sites in Polypharmacology

The literature focuses on drug promiscuity, which is a drug’s ability to bind to several targets, because it plays an essential role in polypharmacology. However, little work has been completed regarding binding site promiscuity, even though its properties are now recognized among the key factors th...

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Detalles Bibliográficos
Autores principales: Cerisier, Natacha, Petitjean, Michel, Regad, Leslie, Bayard, Quentin, Réau, Manon, Badel, Anne, Camproux, Anne-Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680532/
https://www.ncbi.nlm.nih.gov/pubmed/31295958
http://dx.doi.org/10.3390/molecules24142529