Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities

A series of novel coumarin-based hydroxamate derivatives were designed and synthesized as histone deacetylase inhibitors (HDACis). Selective compounds showed a potent HDAC inhibition with nM IC(50) values, with the best compound (10e) being nearly 90 times more active than vorinostat (SAHA) against...

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Detalles Bibliográficos
Autores principales: Yang, Feifei, Zhao, Na, Song, Jiali, Zhu, Kongkai, Jiang, Cheng-shi, Shan, Peipei, Zhang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680717/
https://www.ncbi.nlm.nih.gov/pubmed/31311163
http://dx.doi.org/10.3390/molecules24142569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680717/
https://www.ncbi.nlm.nih.gov/pubmed/31311163
http://dx.doi.org/10.3390/molecules24142569

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