Enhanced Oral Bioavailability of Celecoxib Nanocrystalline Solid Dispersion based on Wet Media Milling Technique: Formulation, Optimization and In Vitro/In Vivo Evaluation

Celecoxib (CLX), a selective COX-2 inhibitor, is a biopharmaceutics classification system (BCS) class II drug with its bioavailability being limited by thepoor aqueoussolubility. The purpose of this study was to develop and optimize CLX nanocrystalline(CLX-NC) solid dispersion prepared by the wet me...

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Detalles Bibliográficos
Autores principales: Ding, Zhuang, Wang, Lili, Xing, Yangyang, Zhao, Yanna, Wang, Zhengping, Han, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680726/
https://www.ncbi.nlm.nih.gov/pubmed/31336734
http://dx.doi.org/10.3390/pharmaceutics11070328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680726/
https://www.ncbi.nlm.nih.gov/pubmed/31336734
http://dx.doi.org/10.3390/pharmaceutics11070328

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