Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-Aβ Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation

In this study, a series of selective butyrylcholinesterase (BChE) inhibitors was designed and synthesized from the structural optimization of hit 1, a 4-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)benzoic acid derivative identified by virtual screening our compound library. The in vitro enzyme assay re...

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Detalles Bibliográficos
Autores principales: Jiang, Cheng-Shi, Ge, Yong-Xi, Cheng, Zhi-Qiang, Wang, Yin-Yin, Tao, Hong-Rui, Zhu, Kongkai, Zhang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680840/
https://www.ncbi.nlm.nih.gov/pubmed/31311169
http://dx.doi.org/10.3390/molecules24142568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680840/
https://www.ncbi.nlm.nih.gov/pubmed/31311169
http://dx.doi.org/10.3390/molecules24142568

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