Cargando…
Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-Aβ Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation
In this study, a series of selective butyrylcholinesterase (BChE) inhibitors was designed and synthesized from the structural optimization of hit 1, a 4-((3,4-dihydroisoquinolin-2(1H)-yl)methyl)benzoic acid derivative identified by virtual screening our compound library. The in vitro enzyme assay re...
Autores principales: | Jiang, Cheng-Shi, Ge, Yong-Xi, Cheng, Zhi-Qiang, Wang, Yin-Yin, Tao, Hong-Rui, Zhu, Kongkai, Zhang, Hua |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680840/ https://www.ncbi.nlm.nih.gov/pubmed/31311169 http://dx.doi.org/10.3390/molecules24142568 |
Ejemplares similares
-
Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations
por: Zhou, You, et al.
Publicado: (2019) -
Biphasic Alteration of Butyrylcholinesterase (BChE) During Prostate Cancer Development
por: Gu, Yan, et al.
Publicado: (2018) -
Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids
por: Guimarães, Larissa O., et al.
Publicado: (2014) -
Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine
por: Garcia, Daniel Fantozzi, et al.
Publicado: (2011) -
Differences in plasmatic butyrylcholinesterases (BChE) values between Pacific and Caribbean populations of terciopelo (Bothrops asper) in Costa Rica
por: Arguedas, Randall, et al.
Publicado: (2019)