Concentration Effects in the Interaction of Monoclonal Antibodies (mAbs) with their Immediate Environment Characterized by EPR Spectroscopy

Monoclonal antibodies (mAbs) are often needed and applied in high concentration solutions, >100 mg/mL. Due to close intermolecular distances between mAbs at high concentrations (~10–20 nm at 200 mg/mL), intermolecular interactions between mAbs and mAbs and solvent/co-solute molecules become non-n...

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Detalles Bibliográficos
Autores principales: Haeri, Haleh H., Blaffert, Jacob, Schöffmann, Florian A., Blech, Michaela, Hartl, Josef, Garidel, Patrick, Hinderberger, Dariush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680867/
https://www.ncbi.nlm.nih.gov/pubmed/31295948
http://dx.doi.org/10.3390/molecules24142528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680867/
https://www.ncbi.nlm.nih.gov/pubmed/31295948
http://dx.doi.org/10.3390/molecules24142528

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