Comparison of Oral, Intranasal and Aerosol Administration of Amiodarone in Rats as a Model of Pulmonary Phospholipidosis

‘Foamy’ alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally administered amiodarone is currently used as a model of pulmonary phospholipidosi...

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Detalles Bibliográficos
Autores principales: Patel, Aateka, Hoffman, Ewelina, Ball, Doug, Klapwijk, Jan, Steven, Rory T., Dexter, Alex, Bunch, Josephine, Baker, Daniel, Murnane, Darragh, Hutter, Victoria, Page, Clive, Dailey, Lea Ann, Forbes, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680908/
https://www.ncbi.nlm.nih.gov/pubmed/31319538
http://dx.doi.org/10.3390/pharmaceutics11070345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680908/
https://www.ncbi.nlm.nih.gov/pubmed/31319538
http://dx.doi.org/10.3390/pharmaceutics11070345

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