Cargando…

Comparison of Oral, Intranasal and Aerosol Administration of Amiodarone in Rats as a Model of Pulmonary Phospholipidosis

‘Foamy’ alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally administered amiodarone is currently used as a model of pulmonary phospholipidosi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patel, Aateka, Hoffman, Ewelina, Ball, Doug, Klapwijk, Jan, Steven, Rory T., Dexter, Alex, Bunch, Josephine, Baker, Daniel, Murnane, Darragh, Hutter, Victoria, Page, Clive, Dailey, Lea Ann, Forbes, Ben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680908/ https://www.ncbi.nlm.nih.gov/pubmed/31319538 http://dx.doi.org/10.3390/pharmaceutics11070345

Ejemplares similares

Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis
por: Dexter, Alex, et al.
Publicado: (2019)

Morphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis
por: Hoffman, Ewelina, et al.
Publicado: (2017)

Increased Density of the Liver and Amiodarone-Associated Phospholipidosis
por: Kojima, Sunao, et al.
Publicado: (2009)

Acute silica toxicity: attenuation by amiodarone-induced pulmonary phospholipidosis.
por: Antonini, J M, et al.
Publicado: (1994)

Amiodarone Hepatotoxicity with Absent Phospholipidosis and Steatosis: A Case Report and Review of Amiodarone Toxicity in Various Organs
por: Cimic, Adela, et al.
Publicado: (2013)

Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits
por: Yamagiwa, Yoshinori, et al.
Publicado: (2016)

Case report of progressive renal dysfunction as a consequence of amiodarone-induced phospholipidosis
por: Duineveld, Mirjam D, et al.
Publicado: (2023)

Investigating the Suitability of High Content Image Analysis as a Tool to Assess the Reversibility of Foamy Alveolar Macrophage Phenotypes In Vitro
por: Hoffman, Ewelina, et al.
Publicado: (2020)

Predicting the mechanism of phospholipidosis
por: Lowe, Robert, et al.
Publicado: (2012)

Attenuation of amiodarone induced lung fibrosis and phospholipidosis in hamsters, by treatment with the platelet activating factor receptor antagonist, WEB 2086
por: Giri, S. N., et al.
Publicado: (1993)

High Content Image Analysis as a Tool to Morphologically Distinguish Macrophage Activation and Determine Its Importance for Foamy Alveolar Macrophage Responses
por: Hoffman, Ewelina, et al.
Publicado: (2021)

Predicting Phospholipidosis Using Machine Learning
por: Lowe, Robert, et al.
Publicado: (2010)

Renal phospholipidosis possibly induced by ranolazine
por: Scheurle, Christoph, et al.
Publicado: (2014)

Evidence for the existence of powder sub-populations in micronized materials: Aerodynamic size-fractions of aerosolized powders possess distinct physicochemical properties.
por: Jaffari, Sara, et al.
Publicado: (2014)

Identification of Drugs Inducing Phospholipidosis by Novel in vitro Data
por: Muehlbacher, Markus, et al.
Publicado: (2012)

Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues
por: Rotimi, Solomon O, et al.
Publicado: (2015)

Different Sensitivity of Macrophages to Phospholipidosis Induction by Amphiphilic Cationic Drugs
por: Öhlinger, Kristin, et al.
Publicado: (2020)

Pulmonary aerosol delivery and the importance of growth dynamics
por: Haddrell, Allen E, et al.
Publicado: (2017)

Curvilinear bodies in hydroxychloroquine-induced renal phospholipidosis resembling Fabry disease
por: Costa, Rui M., et al.
Publicado: (2013)

Inhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis
por: Hinkovska-Galcheva, Vania, et al.
Publicado: (2021)

Use of 3D Human Liver Organoids to Predict Drug-Induced Phospholipidosis
por: Lee, Ji-Young, et al.
Publicado: (2020)

Zebra Body Formation Due to Drug-Induced Phospholipidosis Observed on Electron Micrographs
por: Kawahara, Hiroshi, et al.
Publicado: (2021)

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
por: Tummino, Tia A., et al.
Publicado: (2021)

Water Uptake by Evaporating pMDI Aerosol Prior to Inhalation Affects Both Regional and Total Deposition in the Respiratory System
por: Legh-Land, Victoria, et al.
Publicado: (2021)

Amiodarone: Amiodarone-induced thyrotoxicosis: case report
Publicado: (2022)

Protein aerosol for intranasal nose to brain (N2B) delivery
por: Stützle, Martina, et al.
Publicado: (2015)

High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis
por: Pradip, Arvind, et al.
Publicado: (2016)

Post-transplant de-novo renal phospholipidosis in a kidney transplant recipient: Fabry disease or something else?
por: Naseer, Muhammad Saad, et al.
Publicado: (2020)

Hydroxychloroquine-induced renal phospholipidosis resembling Fabry disease in undifferentiated connective tissue disease: A case report
por: Wu, Song-Zhao, et al.
Publicado: (2019)

Amiodarone in the aged
por: Srinivasan, Meera, et al.
Publicado: (2019)

Aerosol and Contact Transmission Following Intranasal Infection of Mice with Japanese Encephalitis Virus
por: Chai, Chunxia, et al.
Publicado: (2019)

Hydroxychloroquine: Acute kidney injury, prolonged QTC interval and renal phospholipidosis following off-label use: case report
Publicado: (2021)

A Case of Amiodarone Pulmonary Toxicity with Short-term Amiodarone Use
por: McDonald, Abigail
Publicado: (2020)

Pulsatile Bi-Directional Aerosol Flow Affects Aerosol Delivery to the Intranasal Olfactory Region: A Patient-Specific Computational Study
por: Farnoud, Ali, et al.
Publicado: (2021)

Amiodarone and the thyroid dysfunction
por: Jastrzębska, Helena
Publicado: (2013)

Adverse reactions of Amiodarone
por: Colunga Biancatelli, Ruben ML, et al.
Publicado: (2019)

AMIODARONE AND THYROID DYSFUNCTION
por: Medić, Filip, et al.
Publicado: (2022)

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2
por: Tummino, Tia A., et al.
Publicado: (2021)

Rapid characterisation of the inherent dispersibility of respirable powders using dry dispersion laser diffraction
por: Jaffari, Sara, et al.
Publicado: (2013)

Drug-induced phospholipidosis is not correlated with the inhibition of SARS-CoV-2 - inhibition of SARS-CoV-2 is cell line-specific
por: Diesendorf, Viktoria, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4a083o39o27jd60na2e84e4fc9