pH-Sensitive Chitosan–Heparin Nanoparticles for Effective Delivery of Genetic Drugs into Epithelial Cells

Chitosan has been extensively studied as a genetic drug delivery platform. However, its efficiency is limited by the strength of DNA and RNA binding. Expecting a reduced binding strength of cargo with chitosan, we proposed including heparin as a competing polyanion in the polyplexes. We developed ch...

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Detalles Bibliográficos
Autores principales: Pilipenko, Iuliia, Korzhikov-Vlakh, Viktor, Sharoyko, Vladimir, Zhang, Nan, Schäfer-Korting, Monika, Rühl, Eckart, Zoschke, Christian, Tennikova, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680926/
https://www.ncbi.nlm.nih.gov/pubmed/31284414
http://dx.doi.org/10.3390/pharmaceutics11070317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680926/
https://www.ncbi.nlm.nih.gov/pubmed/31284414
http://dx.doi.org/10.3390/pharmaceutics11070317

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