Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-κB, mTOR, Wnt Signalling Pathways

Neuropathy is a complication that affects more than 50% of long-standing diabetic patients. One of the causes of diabetes neuropathy (DN) is the apoptosis of Schwann cells due to prolonged exposure to high glucose and build-up of oxidative stress. Melatonin is a hormone that has a known antioxidant...

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Detalles Bibliográficos
Autores principales: Tiong, Yee Lian, Ng, Khuen Yen, Koh, Rhun Yian, Ponnudurai, Gnanajothy, Chye, Soi Moi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680940/
https://www.ncbi.nlm.nih.gov/pubmed/31247931
http://dx.doi.org/10.3390/antiox8070198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680940/
https://www.ncbi.nlm.nih.gov/pubmed/31247931
http://dx.doi.org/10.3390/antiox8070198

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