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Looking for protein stabilizing drugs with thermal shift assay

Thermal shift assay can be used for the high‐throughput screening of pharmacological chaperones. These drugs are small molecules that bind a mutant protein and stabilize it. We demonstrated the robustness, reproducibility and versatility of the method using two molecules that are in clinical trial f...

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Detalles Bibliográficos
Autores principales: Andreotti, Giuseppina, Monticelli, Maria, Cubellis, Maria Vittoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681132/
https://www.ncbi.nlm.nih.gov/pubmed/25845367
http://dx.doi.org/10.1002/dta.1798