Novel Derivatives of Deoxycholic Acid Bearing Linear Aliphatic Diamine and Aminoalcohol Moieties and their Cyclic Analogs at the C3 Position: Synthesis and Evaluation of Their In Vitro Antitumor Potential

A series of novel deoxycholic acid (DCA) derivatives containing aliphatic diamine and aminoalcohol or morpholine moieties at the C3 position were synthesized by 3,26-epoxide ring-opening reactions. These compounds were investigated for their cytotoxicity in four human tumor cell lines and murine mac...

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Detalles Bibliográficos
Autores principales: Markov, Andrey V., Babich, Valeriya O., Popadyuk, Irina I., Salomatina, Oksana V., Logashenko, Evgeniya B., Salakhutdinov, Nariman F., Zenkova, Marina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681416/
https://www.ncbi.nlm.nih.gov/pubmed/31330911
http://dx.doi.org/10.3390/molecules24142644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681416/
https://www.ncbi.nlm.nih.gov/pubmed/31330911
http://dx.doi.org/10.3390/molecules24142644

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