Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson’s disease

Type-1 reactions (T1R) are pathological inflammatory episodes and main contributors to nerve damage in leprosy. Here, we evaluate the genewise enrichment of rare protein-altering variants in 7 genes where common variants were previously associated with T1R. We selected 474 Vietnamese leprosy patient...

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Detalles Bibliográficos
Autores principales: Fava, Vinicius M., Xu, Yong Zhong, Lettre, Guillaume, Van Thuc, Nguyen, Orlova, Marianna, Thai, Vu Hong, Tao, Shao, Croteau, Nathalie, Eldeeb, Mohamed A., MacDougall, Emma J., Cambri, Geison, Lahiri, Ramanuj, Adams, Linda, Fon, Edward A., Trempe, Jean-François, Cobat, Aurélie, Alcaïs, Alexandre, Abel, Laurent, Schurr, Erwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681704/
https://www.ncbi.nlm.nih.gov/pubmed/31308240
http://dx.doi.org/10.1073/pnas.1901805116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681704/
https://www.ncbi.nlm.nih.gov/pubmed/31308240
http://dx.doi.org/10.1073/pnas.1901805116

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