The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage

The type I TGFβ receptor TGFβRI (encoded by Tgfbr1) was ablated in cartilage. The resulting Tgfbr1(Col2) mice exhibited lethal chondrodysplasia. Similar defects were not seen in mice lacking the type II TGFβ receptor or SMADs 2 and 3, the intracellular mediators of canonical TGFβ signaling. However,...

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Detalles Bibliográficos
Autores principales: Wang, Weiguang, Chun, Hyelim, Baek, Jongseung, Sadik, Joshua Elyahu, Shirazyan, Anna, Razavi, Peyman, Lopez, Noah, Lyons, Karen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681752/
https://www.ncbi.nlm.nih.gov/pubmed/31311865
http://dx.doi.org/10.1073/pnas.1902927116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681752/
https://www.ncbi.nlm.nih.gov/pubmed/31311865
http://dx.doi.org/10.1073/pnas.1902927116

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